Advancing the Understanding and Treatment of Neurological Disorders through Molecular Research
Our Research Projects
The gut microbiome has been implicated in numerous neurodegenerative diseases. We were the first to demonstrate that modulation of the gut microbiome of Alzheimer's disease (AD) mice results in improved cognition and pathology (Left - non-treated; Right - treated for 7 days). We are now investigating mechanisms driving these changes in the brain as they will highlight therapeutic avenues for disease modification.
Astrocytes and microglia play an important role in the maintenance of a homestatic environment in the brain. They aid in the clearance of dead and dying cells, preventing inflammatory reactions in the brain. During Alzheimer's disease, these two classes of cells turn rogue and contribute to disease pathology.
Dr Holsinger is Head of the Laboratory of Molecular Neuroscience and Dementia at The University of Sydney in Australia. He is an academic with both teaching and research duties. He lectures in numerous areas of science and medicine including molecular biology, protein chemistry, biochemistry, cell biology, neuroscience, neurology and neurodegeneration.
Dr Holsinger's research covers similar topics to those listed above with techniques expanding across cell, mouse models and human tissue.