Laboratory of Molecular Neuroscience and Dementia
Advancing the Understanding and Treatment of Neurological Disorders through Molecular Research
Our Research Projects
Involvement of gut microbiota in Alzheimer's disease
The gut microbiome has been implicated in numerous neurodegenerative diseases. We were the first to demonstrate that modulation of the gut microbiome of Alzheimer's disease (AD) mice results in improved cognition and pathology (Left - non-treated; Right - treated for 7 days). We are now investigating mechanisms driving these changes in the brain as they will highlight therapeutic avenues for disease modification.
Glial activity as a marker of disease
Astrocytes and microglia play an important role in the maintenance of a homestatic environment in the brain. They aid in the clearance of dead and dying cells, preventing inflammatory reactions in the brain. During Alzheimer's disease, these two classes of cells turn rogue and contribute to disease pathology.
Join our new endeavour - MAESTRO - dreaMers And doErs: the Scientists of TomorROw
A platform for postgraduate student presentations
Register to hear from our future scientists every Tuesday at 10am GMT
https://tinyurl.com/maestrotalks
